Modified Step Variational Iteration Method for Solving Fractional Biochemical Reaction Model

A new method called the modification of step variational iteration method (MoSVIM) is introduced and used to solve the fractional biochemical reaction model. The MoSVIM uses general Lagrange multipliers for construction of the correction functional for the problems, and it runs by step approach, which is to divide the interval into subintervals with time step, and the solutions are obtained at each subinterval as well adopting a nonzero auxiliary parameter ℏ to control the convergence region of series' solutions. The MoSVIM yields an analytical solution of a rapidly convergent infinite power series with easily computable terms and produces a good approximate solution on enlarged intervals for solving the fractional biochemical reaction model. The accuracy of the results obtained is in a excellent agreement with the Adam Bashforth Moulton method (ABMM)

Light database encryption design utilizing multicore processors for mobile devices

The confidentiality of data stored in embedded and handheld devices has become an urgent necessity more than ever before. Encryption of sensitive data is a well-known technique to preserve their confidentiality, however it comes with certain costs that can heavily impact the device processing resources. Utilizing multicore processors, which are equipped with current embedded devices, has brought a new era to enhance data confidentiality while maintaining suitable device performance. Encrypting the complete storage area, also known as Full Disk Encryption (FDE) can still be challenging, especially with newly emerging massive storage systems. Alternatively, since the most user sensitive data are residing inside persisting databases, it will be more efficient to focus on securing SQLite databases, through encryption, where SQLite is the most common RDBMS in handheld and embedded systems. This paper addresses the problem of ensuring data protection in embedded and mobile devices while maintaining suitable device performance by mitigating the impact of encryption. We presented here a proposed design for a parallel database encryption system, called SQLite-XTS. The proposed system encrypts data stored in databases transparently on-the-fly without the need for any user intervention. To maintain a proper device performance, the system takes advantage of the commodity multicore processors available with most embedded and mobile devices

Numerical algorithm for solving second order nonlinear fuzzy initial value problems

The purpose of this analysis would be to provide a computational technique for the numerical solution of second-order nonlinear fuzzy initial value (FIVPs). The idea is based on the reformulation of the fifth order Runge Kutta with six stages (RK56) from crisp domain to the fuzzy domain by using the definitions and properties of fuzzy set theory to be suitable to solve second order nonlinear FIVP numerically. It is shown that the second order nonlinear FIVP can be solved by RK56 by reducing the original nonlinear equation intoa system of couple first order nonlinear FIVP. The findings indicate that the technique is very efficient and simple to implement and satisfy the Fuzzy solution properties. The method’s potential is demonstrated by solving nonlinear second-order FIVP

Direct solution of uncertain bratu initial value problem

In this paper, an approximate analytical solution for solving the fuzzy Bratu equation based on variation iteration method (VIM) is analyzed and modified without needed of any discretization by taking the benefits of fuzzy set theory. VIM is applied directly, without being reduced to a first order system, to obtain an approximate solution of the uncertain Bratu equation. An example in this regard have been solved to show the capacity and convenience of VIM

The Role of Media in Educational Social Construction of Children with Special Needs

This study tries to explore the function that the media plays in supporting the social construction process within the context of inclusive education services. The impact of the media is one of the multiple variables that contribute to the broad adoption of inclusive education. Other contributing aspects include: To be more specific, what part do different kinds of media play in the social construction that makes up inclusive education? It is vital to do qualitative research to shed light on the function that the media plays in building and inviting classrooms to create. The selection of the test population to evaluate the performance of the inclusive education program required a great deal of attention to detail and consideration. The data for this research was gathered using a variety of methods, including observation, interviews, and written records. When looking at the data that was acquired, a descriptive qualitative analysis was performed. It has been found, after considerable discussion, that the speed with which social construction may occur in the classroom is closely tied to the efficacy of the media in aiding student comprehension. This conclusion was reached after much deliberation

Multistage optimal homotopy asymptotic method for solving initial-value problems

In this paper, a new approximate analytical algorithm namely multistage optimal homotopy asymptotic method (MOHAM) is presented for the first time to obtain approximate analytical solutions for linear, nonlinear and system of initial value problems (IVPs).This algorithm depends on the standard optimal homotopy asymptotic method (OHAM), in which it is treated as an algorithm in a sequence of subinterval. The main advantage of this study is to obtain continuous approximate analytical solutions for a long time span.Numerical examples are tested to highlight the important features of the new algorithm.Comparison of the MOHAM results, standard OHAM, available exact solution and the fourth-order Runge Kutta (RK4) reveale that this algorithm is effective, simple and more impressive than the standard OHAM for solving IVPs

METHOD DEVELOPMENT AND VALIDATION OF THE CHROMATOGRAPHIC ANALYSIS OF FLUTICASONE PROPIONATE AND SALMETEROL XINAFOATE COMBINATION IN SOLUTIONS AND HUMAN PLASMA USING HPLC WITH UV DETECTION

Objective: A simple, Rapid, and sensitive HPLC method utilizing UV detection was developed and validated for the simultaneous estimation of Fluticasone propionate (FP) and Salmeterol xinafoate (SX) in solutions and in vitro human plasma. Methods: Chromatographic analysis was done on SUPELCO® RP-C18 column (150 x 4.6 mm, 5 μm particle size) with an isocratic mobile phase composed of methanol, acetonitrile, and water (50:20:30, v/v) mixture while flow rate was set to 1 ml/min. Detection with UV at maximum absorbance wavelength (ʎmax) values of 236 and 252 for FP and SX, respectively. Spiked plasma samples were liquid-liquid extracted by diethyl ether and reconstituted using methanol. Results: Method was accurate and precise over a linear (R2>0.995) range of (0.067-100 µg/ml) and (0.0333-50 µg/ml) for FP and SX, respectively. LOD/lOQ values were 0.13/0.6 and 0.06/0.3 µg/ml for FP and SX, respectively. The developed method was successfully applied for the analysis of FP and SX in spiked human plasma samples. The method is considered to be accurate and precise over a linear (R2>0.9969) range of (6.67-66.67 µg/ml) and (3.33-33.3 µg/ml) for FP and SX, respectively. Extraction efficiency was approved by recovery values of (94.98–102.46 %) and (96.54–102.62 %) for FP and SX, respectively. Conclusion: This validated method revealed simple and cheap extraction procedures and detectors, non-buffered mobile phase, and short retention times with excellent resolution

High- and low-affinity PEGylated hemoglobin-based oxygen carriers: differential oxidative stress in a Guinea pig transfusion model

Hemoglobin (Hb)-based oxygen carriers (HBOCs) are an investigational replacement for blood transfusions and are known to cause oxidative damage to tissues. To investigate the correlation between their oxygen binding properties and these detrimental effects, we investigated two PEGylated HBOCs endowed with different oxygen binding properties - but otherwise chemically identical - in a Guinea pig transfusion model. Plasma samples were analyzed for biochemical markers of inflammation, tissue damage and organ dysfunction; proteins and lipids of heart and kidney extracts were analyzed for markers of oxidative damage. Overall, both HBOCs produced higher oxidative stress in comparison to an auto-transfusion control group. Particularly, tissue 4-hydroxynonenal-adducts, tissue malondialdehyde adducts and plasma 8-oxo-2'-deoxyguanosine exhibited significantly higher levels in comparison with the control group. For malondialdehyde adducts, a higher level in the renal tissue was observed for animals treated with PEG-Hboxy, hinting at a correlation between the HBOCs oxygen binding properties and the oxidative stress they produce. Moreover, we found that the high-affinity HBOC produced greater tissue oxygenation in comparison with the low affinity one, possibly correlating with the higher oxidative stress it induced

Numerical solution of n’th order fuzzy initial value problems by six stages

The purpose of this paper is to present a numerical approach to solve fuzzy initial value problems (FIVPs) involving n-th order ordinary differential equations.The idea is based on the formulation of the six stages Runge-Kutta method of order five (RKM56) from crisp environment to fuzzy environment followed by the stability definitions and the convergence proof.It is shown that the n-th order FIVP can be solved by RKM56 by transforming the original problem into a system of first-order FIVPs. The results indicate that the method is very effective and simple to apply.An efficient procedure is proposed of RKM56 on the basis of the principles and definitions of fuzzy sets theory and the capability of the method is illustrated by solving second-order linear FIVP involving a circuit model problem